{"id":997,"date":"2020-12-22T04:38:00","date_gmt":"2020-12-22T04:38:00","guid":{"rendered":"http:\/\/wp1.chem.rpi.edu\/?page_id=997"},"modified":"2026-09-22T16:52:15","modified_gmt":"2026-09-22T16:52:15","slug":"997-2","status":"publish","type":"page","link":"https:\/\/montelionelab.chem.rpi.edu\/","title":{"rendered":""},"content":{"rendered":"\n<div class=\"wp-block-cover alignfull has-large-font-size\" style=\"padding-top:0;padding-right:var(--wp--preset--spacing--20);padding-bottom:0;padding-left:var(--wp--preset--spacing--20)\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"356\" class=\"wp-block-cover__image-background wp-image-4354 size-large\" alt=\"\" src=\"https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/CBIS-1024x356.jpg\" style=\"object-position:50% 50%\" data-object-fit=\"cover\" data-object-position=\"50% 50%\" srcset=\"https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/CBIS-1024x356.jpg 1024w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/CBIS-300x104.jpg 300w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/CBIS-768x267.jpg 768w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/CBIS.jpg 1500w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-0 has-background-dim\" style=\"background-color:#7d787d\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<h5 class=\"wp-block-heading has-text-align-left has-background-color has-text-color has-background has-link-color wp-elements-1\" style=\"border-radius:10px;background-color:#54585a;padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--40);font-size:30px;font-style:normal;font-weight:600;line-height:1.4\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-background-color\">The Structural Bioinformatics Laboratory at Rensselaer Polytechnic Institute investigates the structural dynamics underlying protein function. Our work utilizes a combination of computational methods and biophysical data to elucidate mechanisms of biological processes.<\/mark><\/h5>\n\n\n\n<div class=\"wp-block-group alignwide mobile-buttons\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-buttons alignwide has-custom-font-size mobile-buttons is-horizontal is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-ade90221 wp-block-buttons-is-layout-flex\" style=\"margin-top:var(--wp--preset--spacing--20);margin-bottom:var(--wp--preset--spacing--20);font-size:18px;font-style:normal;font-weight:700;letter-spacing:1px;line-height:1;text-transform:capitalize\">\n<div style=\"--wp--block-button--width: 25;\" class=\"wp-block-button has-custom-width wp-block-button__width wp-block-button__width-25\"><a class=\"wp-block-button__link has-background-color has-text-color has-background has-border-color has-background-border-color has-small-font-size has-custom-font-size wp-element-button\" href=\"http:\/\/montelionelab.chem.rpi.edu\/index.php\/publications\/\" style=\"border-style:solid;border-width:3px;border-radius:10px;background-color:#d6001c;padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--30);font-style:normal;font-weight:700\">Publications<\/a><\/div>\n\n\n\n<div style=\"--wp--block-button--width: 25;\" class=\"wp-block-button has-custom-width wp-block-button__width wp-block-button__width-25\"><a class=\"wp-block-button__link has-background-color has-text-color has-background has-border-color has-background-border-color has-small-font-size has-custom-font-size wp-element-button\" href=\"http:\/\/montelionelab.chem.rpi.edu\/index.php\/research\/\" style=\"border-style:solid;border-width:3px;border-radius:10px;background-color:#d6001c;padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--30);font-style:normal;font-weight:700\">Research<\/a><\/div>\n\n\n\n<div style=\"--wp--block-button--width: 25;\" class=\"wp-block-button has-custom-width wp-block-button__width wp-block-button__width-25\"><a class=\"wp-block-button__link has-background-color has-text-color has-background has-border-color has-background-border-color has-small-font-size has-custom-font-size wp-element-button\" href=\"http:\/\/montelionelab.chem.rpi.edu\/index.php\/research-facilities\/\" style=\"border-style:solid;border-width:3px;border-radius:10px;background-color:#d6001c;padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--30);font-style:normal;font-weight:700\">Our Facilities<\/a><\/div>\n\n\n\n<div style=\"--wp--block-button--width: 25;\" class=\"wp-block-button has-custom-width wp-block-button__width wp-block-button__width-25\"><a class=\"wp-block-button__link has-background-color has-text-color has-background has-border-color has-background-border-color has-small-font-size has-custom-font-size wp-element-button\" href=\"https:\/\/montelionelab.chem.rpi.edu\/index.php\/team-members-2\/\" style=\"border-style:solid;border-width:3px;border-radius:10px;background-color:#d6001c;padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--30);font-style:normal;font-weight:700\">Our Team<\/a><\/div>\n\n\n\n<div style=\"--wp--block-button--width: 25;\" class=\"wp-block-button mobile-buttons has-custom-width wp-block-button__width wp-block-button__width-25\"><a class=\"wp-block-button__link has-background-color has-text-color has-background has-border-color has-background-border-color has-small-font-size has-custom-font-size wp-element-button\" href=\"https:\/\/montelionelab.chem.rpi.edu\/index.php\/alumni\/\" style=\"border-style:solid;border-width:3px;border-radius:10px;background-color:#d6001c;padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--30);font-style:normal;font-weight:700\">Alumni<\/a><\/div>\n\n\n\n<div style=\"--wp--block-button--width: 25;\" class=\"wp-block-button mobile-buttons has-custom-width wp-block-button__width wp-block-button__width-25\"><a class=\"wp-block-button__link has-background-color has-text-color has-background has-border-color has-background-border-color has-text-align-center has-small-font-size has-custom-font-size wp-element-button\" href=\"http:\/\/montelionelab.chem.rpi.edu\/index.php\/undergrads-trained\/\" style=\"border-style:solid;border-width:3px;border-radius:10px;background-color:#d6001c;padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--30);font-style:normal;font-weight:700\">Undergrads Trained<\/a><\/div>\n<\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<style>\n@media (max-width: 600px) {\n  .mobile-buttons {\n    width: 100% !important;\n    display: flex !important;\n    flex-direction: column !important;\n    align-items: center !important;\n    gap: 12px !important;\n  }\n\n  .mobile-buttons > div {\n    font-size: 14px !important;\n    padding: 2px 10px !important;\n    width: 90% !important;\n    text-align: center !important;\n    word-break: break-word !important;\n    white-space: normal !important;\n    line-height: 1 !important;\n  }\n}\n<\/style>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.3%\">\n<h6 class=\"wp-block-heading has-text-align-center alignwide has-background-color has-text-color has-background has-link-color has-huge-font-size wp-elements-2\" style=\"border-radius:20px;background-color:#000000;letter-spacing:1.5px\"><a href=\"http:\/\/montelionelab.chem.rpi.edu\/index.php\/services\/\"><span style=\"text-decoration: underline;\">Research Highlights<\/span><\/a><\/h6>\n\n\n\n<h6 class=\"wp-block-heading has-text-color has-link-color wp-elements-3\" style=\"color:#7fa9ae\"><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-026-71997-6?utm_source=chatgpt.com\"><strong>Hidden structural states of proteins revealed by conformer selection (2026)<\/strong><\/a><\/span><\/h6>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"276\" height=\"390\" src=\"https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2026\/09\/image-2.png\" alt=\"\" class=\"wp-image-4641\" style=\"aspect-ratio:0.7083333333333334;width:214px;height:auto\" srcset=\"https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2026\/09\/image-2.png 276w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2026\/09\/image-2-212x300.png 212w\" sizes=\"(max-width: 276px) 100vw, 276px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">In this study, our lab introduces <strong>AI Sampling with NMR Recall selection (AISAR)<\/strong>, a framework that uses AI to generate diverse, physically realistic protein conformations and then selects those that best explain experimental NOESY and other NMR data. Unlike conventional approaches that use NMR measurements as structural restraints, AISAR evaluates candidate models to identify multiple conformations in dynamic equilibrium. <strong>NOESY Double Recall analysis<\/strong> then provides experimental validation by identifying signals unique to each state, revealing hidden conformations and cryptic binding pockets that may be important for protein function and drug discovery.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-wide\"\/>\n\n\n\n<h6 class=\"wp-block-heading has-text-color has-link-color wp-elements-4\" style=\"color:#7fa9ae\"><strong><a href=\"https:\/\/doi.org\/10.1126\/science.adr8063\"><span style=\"text-decoration: underline;\">Design of intrinsically disordered region binding protein<\/span><\/a><\/strong><span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1126\/science.adr8063\">s<\/a> (July<strong> 2025)<\/strong><\/span><\/h6>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" width=\"606\" height=\"1024\" src=\"http:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/IDR_bindingPocket-606x1024.png\" alt=\"\" class=\"wp-image-4560\" style=\"width:209px;height:auto\" srcset=\"https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/IDR_bindingPocket-606x1024.png 606w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/IDR_bindingPocket-177x300.png 177w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/IDR_bindingPocket.png 704w\" sizes=\"(max-width: 606px) 100vw, 606px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">In this new&nbsp;<em><strong>Science<\/strong><\/em>&nbsp;paper, our collaborators in the Baker lab used AI-guided design to create proteins that bind tightly and specifically to 39 disordered targets, including the opioid peptide dynorphin, cancer-related receptor regions, and prion-like viral sequences. Together with X-ray crystallography, <strong>our lab validated <\/strong>the dynorphin binders by <strong>NMR<\/strong>, confirming that binding locks the flexible peptide into a defined shape. This modular method can be used to <strong>design binding proteins for virtually any disordered protein or peptide target allowing for the ability to now target the &#8220;untargetable&#8221;.<\/strong><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.3%\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h6 class=\"wp-block-heading has-text-align-center alignwide has-background-color has-text-color has-background has-link-color has-huge-font-size wp-elements-5\" style=\"border-radius:20px;background-color:#ab2328;letter-spacing:2px\"><a href=\"https:\/\/montelionelab.chem.rpi.edu\/index.php\/milestones\/\"><span style=\"text-decoration: underline;\">Recent Milestones<\/span><\/a><\/h6>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rebecca Greene-Cramer<\/strong> was recognized as a <strong>Future Leader<\/strong> at the&nbsp; Eastern New York Chapter of the <strong>American Chemistry Society.<\/strong>&nbsp;She also received <strong>First Place, 3 Minute Thesis<\/strong> (3MT) \u2013 Rensselaer Polytechnic Institute in April 2025, and was awarded the <strong>Bauer Prize for Best Ph.D. Thesis<\/strong> in Chemistry.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"781\" src=\"https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/Screenshot-2025-07-08-at-1.07.01\u202fPM-1024x781.png\" alt=\"\" class=\"wp-image-4297\" srcset=\"https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/Screenshot-2025-07-08-at-1.07.01\u202fPM-1024x781.png 1024w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/Screenshot-2025-07-08-at-1.07.01\u202fPM-300x229.png 300w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/Screenshot-2025-07-08-at-1.07.01\u202fPM-768x586.png 768w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/Screenshot-2025-07-08-at-1.07.01\u202fPM.png 1246w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-group\" style=\"padding-top:0;padding-right:var(--wp--preset--spacing--20);padding-bottom:0;padding-left:var(--wp--preset--spacing--20)\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-container-core-group-is-layout-ac82b853 wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\"><strong>Congratulations to Laura Spaman<\/strong>&nbsp;for&nbsp;<strong>Best Oral Presentation&nbsp;<\/strong>at the&nbsp;<strong>Chemistry Graduate Student Symposium<\/strong>&nbsp;for her scientific talk titled:&nbsp; \u201c<em>AlphaFold2 and Experimental Biophysics: A Synergistic Approach to Understanding Protein Structure and Behavior,<\/em>\u201d on Jan 7, 2025.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"766\" src=\"https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/01\/Screen-Shot-2025-01-13-at-4.08.53-PM-1024x766.png\" alt=\"\" class=\"wp-image-4214\" srcset=\"https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/01\/Screen-Shot-2025-01-13-at-4.08.53-PM-1024x766.png 1024w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/01\/Screen-Shot-2025-01-13-at-4.08.53-PM-300x224.png 300w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/01\/Screen-Shot-2025-01-13-at-4.08.53-PM-768x575.png 768w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/01\/Screen-Shot-2025-01-13-at-4.08.53-PM.png 1136w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-stretch is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--20);flex-basis:33.3%\">\n<h6 class=\"wp-block-heading has-text-align-center alignwide has-huge-font-size\" style=\"letter-spacing:2px\">May 2025<\/h6>\n\n\n\n<div class=\"wp-block-group alignfull\" style=\"padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-container-core-group-is-layout-e38500a2 wp-block-group-is-layout-constrained\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"575\" src=\"http:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/RGCPhD-e1751984247955-1024x575.jpg\" alt=\"\" class=\"wp-image-4285\" srcset=\"https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/RGCPhD-e1751984247955-1024x575.jpg 1024w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/RGCPhD-e1751984247955-300x168.jpg 300w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/RGCPhD-e1751984247955-768x431.jpg 768w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/RGCPhD-e1751984247955-1536x863.jpg 1536w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/RGCPhD-e1751984247955-1568x881.jpg 1568w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2025\/07\/RGCPhD-e1751984247955.jpg 1923w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\" style=\"margin-top:var(--wp--preset--spacing--20);margin-right:var(--wp--preset--spacing--20);margin-bottom:var(--wp--preset--spacing--20);margin-left:var(--wp--preset--spacing--20)\"><strong>Congratulations<\/strong> to <strong>Dr. Rebecca Greene-Cramer<\/strong> for completing a <strong>Ph.D. in Chemistry and Chemical Biology<\/strong>, titled <strong>&#8220;The Pursuit of Broad-Spectrum Antivirals: Leveraging Structural Insights into Viral Proteases&#8221;<\/strong><\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-background-background-color has-background\" style=\"padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--20);font-size:22px\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group alignfull\" style=\"padding-right:0;padding-left:0\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"2357\" height=\"504\" src=\"https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2020\/08\/cropped-rpi-logo-3291552be1396bc906ae9ac50f3ca3c7bf9bc0fdbf2b7999c0f0aae0e8102404-3-2.jpg\" alt=\"\" class=\"wp-image-290\" srcset=\"https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2020\/08\/cropped-rpi-logo-3291552be1396bc906ae9ac50f3ca3c7bf9bc0fdbf2b7999c0f0aae0e8102404-3-2.jpg 2357w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2020\/08\/cropped-rpi-logo-3291552be1396bc906ae9ac50f3ca3c7bf9bc0fdbf2b7999c0f0aae0e8102404-3-2-300x64.jpg 300w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2020\/08\/cropped-rpi-logo-3291552be1396bc906ae9ac50f3ca3c7bf9bc0fdbf2b7999c0f0aae0e8102404-3-2-1024x219.jpg 1024w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2020\/08\/cropped-rpi-logo-3291552be1396bc906ae9ac50f3ca3c7bf9bc0fdbf2b7999c0f0aae0e8102404-3-2-768x164.jpg 768w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2020\/08\/cropped-rpi-logo-3291552be1396bc906ae9ac50f3ca3c7bf9bc0fdbf2b7999c0f0aae0e8102404-3-2-1536x328.jpg 1536w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2020\/08\/cropped-rpi-logo-3291552be1396bc906ae9ac50f3ca3c7bf9bc0fdbf2b7999c0f0aae0e8102404-3-2-2048x438.jpg 2048w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2020\/08\/cropped-rpi-logo-3291552be1396bc906ae9ac50f3ca3c7bf9bc0fdbf2b7999c0f0aae0e8102404-3-2-1200x257.jpg 1200w, https:\/\/montelionelab.chem.rpi.edu\/wp-content\/uploads\/2020\/08\/cropped-rpi-logo-3291552be1396bc906ae9ac50f3ca3c7bf9bc0fdbf2b7999c0f0aae0e8102404-3-2-1980x423.jpg 1980w\" sizes=\"(max-width: 2357px) 100vw, 2357px\" \/><\/figure>\n<\/div>\n\n\n<div class=\"wp-block-group alignwide\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"has-text-align-center has-small-font-size wp-block-paragraph\"><strong>Statement of Accessibility<\/strong> &nbsp;<a href=\"https:\/\/info.rpi.edu\/statement-of-accessibility\">https:\/\/info.rpi.edu\/statement-of-accessibility<\/a><\/p>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Highlights Hidden structural states of proteins revealed by conformer selection (2026) In this study, our lab introduces AI Sampling with NMR Recall selection (AISAR), a framework that uses AI to generate diverse, physically realistic protein conformations and then selects those that best explain experimental NOESY and other NMR data. Unlike conventional approaches that use<a class=\"more-link\" href=\"https:\/\/montelionelab.chem.rpi.edu\/\">Continue reading <\/a><\/p>\n","protected":false},"author":11,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-997","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/montelionelab.chem.rpi.edu\/index.php\/wp-json\/wp\/v2\/pages\/997","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/montelionelab.chem.rpi.edu\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/montelionelab.chem.rpi.edu\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/montelionelab.chem.rpi.edu\/index.php\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/montelionelab.chem.rpi.edu\/index.php\/wp-json\/wp\/v2\/comments?post=997"}],"version-history":[{"count":368,"href":"https:\/\/montelionelab.chem.rpi.edu\/index.php\/wp-json\/wp\/v2\/pages\/997\/revisions"}],"predecessor-version":[{"id":4645,"href":"https:\/\/montelionelab.chem.rpi.edu\/index.php\/wp-json\/wp\/v2\/pages\/997\/revisions\/4645"}],"wp:attachment":[{"href":"https:\/\/montelionelab.chem.rpi.edu\/index.php\/wp-json\/wp\/v2\/media?parent=997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}