RPI Structural Bioinformatics Lab
The Rensselaer Polytechnic Institute Structural Bioinformatics Laboratory pursues dynamic structure – function studies of proteins. The lab combines computational methods with biophysical data to elucidate mechanisms of biological processes.
Proposed mechanism by which FDA-approved hepatitis C virus (HCV) drugs synergize with the SARS-CoV-2 antiviral remdesivir
Research Highlights
Hepatitis C virus drugs inhibit SARS-CoV-2 PLpro and act synergistically with the antiviral remdesivir. Cell Reports 2021
Comparison of (left) backbone and (right) sidechain structures of NMR (green) and AlphaFold2 model (blue) of CASP target T1055.
Assessment of prediction methods for protein structures determined by NMR in CASP14: Impact of AlphaFold2. PROTEINS 2021. Article
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Milestones
Welcome to Ms. Allison Martin, Masters of Engineering in Materials Science at Rensselaer Polytechnic Institute, December 2021, starting as Research Specialist in our lab!
RPI Faculty Awarded Shared Instrument Grants for 800 MHz NMR System Upgrade and Helium Recovery System. Article.
Congratulations to Dr. Ben Shurina, completed Ph.D. in Structural Biology from Miami University, Miami OH. December 2021. And welcome to our lab!!
Congratulations to Ms. Rebecca Greene-Cramer, selected for NIH Biotechnology Graduate Training Grant Program.
Congratulations to Ms. Jingzhou Hao, accepted to the Graduate Program in Molecular Biophysics at Johns Hopkins University.
1921 – 2020
Harold A. Scheraga
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Harold was gifted with a unique combination of intensity and breadth of vision. He realized early in his career that both experimental and theoretical work would be necessary to solve the central problems of protein science, and, most unusually, he excelled in both spheres.
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