RPI Structural Bioinformatics Lab
The Rensselaer Polytechnic Institute Structural Bioinformatics Laboratory pursues dynamic structure – function studies of proteins. The lab combines computational methods with biophysical data to elucidate mechanisms of biological processes.
Proposed mechanism by which FDA-approved hepatitis C virus (HCV) drugs synergize with the SARS-CoV-2 antiviral remdesivir
Research Highlights
Hepatitis C virus drugs simeprevir and grazoprevir synergize with remdesivir to suppress SARS-CoV-2 replication. bioRxiv 2020
Interdomain dynamics in a complex formed between Maloney Leukemia Virus and a host chromatin-associated protein
Milestones
Congratulations to Ms. Jingzhou Hao, awarded Highest Honors for her Rutgers University undergraduate research thesis Conformational Dynamics of Murine Leukemia Virus Integrase in its Complex with Chromosomal Bromodomain-Containing Protein 3 bioRxiv 2020 Structure 2021.
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Harold A. Scheraga
Harold was gifted with a unique combination of intensity and breadth of vision. He realized early in his career that both experimental and theoretical work would be necessary to solve the central problems of protein science, and, most unusually, he excelled in both spheres.
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